Dihexa (PNB 0408) c Met HGFR Activator MedChemExpress The Therapeutic Targeting of HGF c Met Signaling in Hepatocellular Carcinoma: Alternative Approaches A novel agonist for the HGF receptor MET promotes differentiation of human pluripotent stem cells into hepatocytelike cells Tauran 2022 Development, Growth & Differentiation Wiley Online Library Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted Dihexa is an experimental cognitive peptide that may help the brain build stronger connections between neurons instead of just temporarily boosting neurotransmitters like many nootropics do. It works through the HGF c Met pathway,