PDF] Evidence that Increased Acetaminophen use in Genetically Vulnerable Children Appears to be a Major Cause of the Epidemics of Autism, Attention Deficit with Hyperactivity, and Asthma Semantic Scholar Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification Xia & He Publishing Full article: The development and hepatotoxicity of acetaminophen: reviewing over a century of progress