Acetaminophen's Role in Autism and ADHD: A Mitochondrial Perspective Tylenol's Impact on Glutathione and Liver Damage GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism of acetaminophen and Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification